ABSTRACT
Background: The strong indicator of malignant transformation potential of certain lesion is the change in the expression of proteins which are related to cell proliferation and apoptosis. Earlier studies suggest that oral lichen planus shows a possibility of malignant transformation to squamous cell carcinoma, therefore the diagnosis of oral lichen planus in the initial stages is not an error in diagnosis but it shows that in due course of time it has transformed into squamous cell carcinoma. Aim & Objective: The aim is to analyze the expression of p53 and PCNA in oral epithelial dysplasia,oral squammous cell carcinoma.Both the differences and combined immunoexpressions was studied. Methodology: 40 cases were taken, 10 cases each of dysplastic tissue, oral lichen planus, oral squamous cell carcinoma and buccal mucosa. Immunohistochemistery was done to analyze p53 and PCNA expression. Result: The results of this study exhibited the alterations in the expression of these proteins as observed in Lichen planus and epithelial dysplasia conforming the potential for malignant transformation of both lesions.
KEYWORDS:p53 & PCNA, Oral Epithelial Dysplasia, Oral Lichen Planus, Oral Squamous Cell Carcinoma, Immunohistochemical Study